Muscle and joint-related/rheumatological manifestationsMuscle and joint-related and rheumatological manifestations can affect patients throughout their lives. Calcification of soft tissue and joints is common with hypophosphatasia and complications include:

  • Muscle weakness
  • Chronic pain
  • Chondrocalcinosis
  • Pseudogout
  • Osteoarthropathy
  • Arthritis

Berkseth KE et al. Bone 2013; 54: 21-27.
Chuck AJ et al. Ann Rheum Dis 1989; 48: 571-576.
Guañabens N et al. J Bone Miner Res 2014; 29: 929-934.
Seshia SS et al. Arch Dis Child 1990; 65: 130-131.
Whyte MP et al. Am J Med 1982; 72: 631-641.


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SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
DIAGNOSES/CONDITIONS READ MORE
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